Bayer Leverkusen and Real Betis meet again on Thursday evening, two weeks after their last Europa League encounter – this time at the BayArena.
The teams could not be separated a fortnight ago, playing out a 1-1 draw, and remain level on seven points at the top of Group G.
Die Werkself have something of an injury crisis on their hands currently, particularly in midfield and attack.
Forwards Patrik Schick and Emrehan Gedikli are both out with ankle issues, whilst Seoane is without four midfielders – Charles Aranguiz, Exequiel Palacios, Karim Bellarabi and Julian Baumgartlinger.
They can at least welcome back Moussa Diaby, who missed the home defeat to Wolfsburg at the weekend through suspension.
Defender Youssouf Sabaly is out with a muscle injury for Betis, but former Arsenal man Hector Bellerin may have recovered from a stomach issue in time to feature.
Nabil Fekir was surprisingly an unused substitute in the defeat to Atletico so will surely return to the number 10 role on Thursday.
Bayer Leverkusen possible starting lineup:
Hradecky; Frimpong, Kossounou, Tah, Hincapie; Andrich, Demirbay; Diaby, Wirtz, Paulinho; Alario
Real Betis possible starting lineup:
Bravo; Montoya, Pezzella, Gonzalez, Miranda; Guardado, Carvalho; Joaquin, Fekir, Ruibal; Iglesias
Over 7.5 Corners