Tottenham Hotspur play host to Wolverhampton Wanderers on Saturday afternoon looking to extend their unbeaten start to the new Premier League campaign.
While Spurs occupy fourth spot in the standings, Wolves are down in 14th position having failed to defeat either Leeds United or Fulham.
With Cristian Romero having sustained a muscle injury, either Clement Lenglet, Davinson Sanchez or Japhet Tanganga will be drafted into the Spurs backline.
Providing that there are no other fitness issues, that is likely to be the solitary change with Richarlison having to make do with a spot on the substitutes’ bench.
This fixture will come too soon for Oliver Skipp, who is making progress in his recovery from a hairline fracture of his heel.
Nunes will almost certainly start this contest among the replacements having had just two days to train with his new Wolves teammates.
Guedes may be considered for a start ahead of Hwang Hee-chan, but Nelson Semedo, Joao Moutinho and Adama Traore are likely to be kept in reserve after their recent injuries.
Tottenham Hotspur possible starting lineup:
Lloris; Sanchez, Dier, Davies; Emerson, Hojbjerg, Bentancur, Sessegnon; Kulusevski, Kane, Son
Wolverhampton Wanderers possible starting lineup:
Sa; Jonny, Collins, Kilman, Ait-Nouri; Dendoncker, Neves; Podence, Gibbs-White, Neto; Hwang
Home to Win (-1) Handicap